Studies on Toluene Diisocyanate (TDI)-lnduced Delayed Type Hypersensitivity

Two cases of paraoccupational asthma due to toluene diisocyanate (TDI).

Two cases of paraoccupational asthma caused by toluene diisocyanate (TDI) are reported. The first patient was a metal worker in a machine shop situated near a factory producing polyurethane foam. Symptoms at work were not explainable by any specific exposure to irritants or allergens in the work site. As the patient recalled previous occasional work in the adjacent polyurethane factory with acc...

[Cohort studies of effects of long-term toluene diisocyanate (TDI) exposure on pulmonary function].

Toluene diisocyanates (C6H3CH3 (NCO)2, TDIs) are synthetic low molecular-weight organic chemicals with two highly reactive isocyanate groups (-NCO). Exposure to TDI can cause irritation of the eyes, nose, and upper and lower respiratory tract, asthma-like responses, sensitive pneumonitis, and obstructive pulmonary function loss. In this paper, the exposure-effect relationships between long-term...

Experimental model of asthma by toluene diisocyanate (TDI).

Epidemiology of toluene diisocyanate (TDI)-induced respiratory disease.

This paper describes our experience with the respiratory effects of TDI. Five respiratory reactions attributable to TDI are described with supporting evidence. The reactions are sensitization, irritation from overexposure, acute loss of ventilatory capacity, accelerated loss of pulmonary function and induction of a general asthmatic state. Evidence is presented that suggests a safe exposure level.

luene diisocyanate (TDI) isease: Immunologic and inhalation challenge studies

Clinical and serologic effects of TDI exposure were studied in 112 occupationally exposed plant workers. Sera were obtained before and after commencement of TDI production. A11 subjects were skin-tested with common inhalant allergens and a TDI-HSA conju.gate. Total eosinophil counts, immunoglobuliw quantitatioas, fina specific antibody assays by PCA, P-E, and ~adioimmunoassay were performed. Cl...